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Dosage and Administration
Swallowing alprazolam tablets is the safest route of use. Take XANAX (Alprazolam) exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much XANAX (Alprazolam) to take and when to take it.
Initially, 0.25 mg to 0.5 mg PO 3 times per day. Use the lower dose for debilitated adults initially. If clinically indicated, increase the dose as tolerated at intervals of 3 to 4 days, up to a maximum of 4 mg/day in divided doses.
Max: 0.02 mg/kg/dose PO or 0.06 mg/kg/day PO. In another study of children with overanxious or avoidant disorder (n = 30), initial doses were 0.25 mg PO per day for children 40 kg or less and 0.5 mg PO per day for those more than 40 kg. Doses were titrated at 2-day intervals to a maximum of 0.04 mg/kg/day. Required doses ranged from 0.5 mg to 3.5 mg/day with a mean dose of 1.6 mg/day.
Generally,all patients should reduce their dosage gradually when discontinuing therapy or when decreasing the daily dosage.
Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every 3 days. Some patients may require an even slower dosage reduction.
Treatment of many panic disorder patients has required the use of XANAX(Alprazolam) at doses greater than 4 mg daily. In controlled trials conducted to establish the efficacy of XANAX(Alprazolam) in panic disorder, doses in the range of 1 to 10 mg daily were used. The mean dosage employed was approximately 5 to 6 mg daily. Among the approximately 1700 patients participating in the panic disorder development program, about 300 received XANAX(Alprazolam) in dosages of greater than 7 mg/day, including approximately 100 patients who received maximum dosages of greater than 9 mg/day. Occasional patients required as much as 10 mg a day to achieve a successful response.
Central Nervous System
Certain adverse clinical events, some life-threatening, are a direct consequence of physical dependence to XANAX. These include a spectrum of withdrawal symptoms; the most important is seizure (see Drug Abuse And Dependence).